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The nervous system allows an organism to sense and interact with its environment. Amongst the many factors that underlie nervous system function is the capacity of neurons to integrate information from many other neurons, to be excitable, and to modify their function based upon experience. The research performed by the investigators associated with the Physiology Department utilizes cutting edge, multidisciplinary approaches to understand how neuronal excitability and interconnectivity develops, is maintained and is negatively impacted by aging or injury. The neuroscience group at SIU has members located in several departments on the Carbondale and Springfield campuses. Interactions among the group are promoted through the Neuroscience Journal Club, Neuroscience Seminar Series CIR-CNS (CIR-CNS http://www.siumed.edu/circns/index.html) and biennial meeting of the local and regional chapters of the Society for Neuroscience.