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Department of Physiology

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Metabolism

The regulation of energy balance is achieved through a matching of energy intake (calories consumed) and energy expenditure (calories burned). Perturbations in either intake or expenditure can result in a negative or positive energy balance (obesity). Obesity and its' associated co-morbid conditions claim the lives of over 200,000 people per year. Research in the Strader Obesity research lab has two primary interests 1) understanding the role of the central nervous system in the regulation of energy balance and 2) understanding the role of the periphery (specifically the gastrointestinal system) in the regulation of food intake and glucose homeostasis. Presently, obesity is most effectively treated with obesity surgery. The gold standard procedure, gastric bypass, causes massive and durable weight loss in addition to markedly improved or "cured" co-morbid conditions such as type-II diabetes. Much of our research is dedicated to understanding the mechanisms underlying the glucose lowering effect of obesity surgery.

Faculty doing Metabolism Research:
April Strader, PhD.
James MacLean II, PhD.